Maintenance period and dose
Can a lower Mounjaro dose maintain weight loss after reaching your goal?
A new trial begins to answer: After reducing the dose, does everyone need to maintain the original high dose?
After reaching the target, we can discuss reducing the dose, but how much to reduce and how to track it still depends on the individual situation, and we cannot directly change the medicine on our own according to the research.
How do studies compare maintenance doses?
In SURMOUNT-MAINTAIN, participants received tirzepatide for 60 weeks; then 378 people were randomly assigned to continue on 10 or 15 mg as tolerated, drop to 5 mg weekly, or switch to placebo, and were followed for an additional 52 weeks.
The effect is still maintained after dose reduction, but it is not as good as the original dose.
Overall, both continuing the original dose and reducing it to 5 mg were better than placebo in maintaining weight loss; continuing the original dose was better at maintaining weight loss. This provides a research basis for weight reduction and maintenance, but it does not mean that everyone can maintain the same weight after reducing weight.
You cannot reduce the dose directly according to the research.
Participants first received treatment for a longer period of time, and the study also included rescue treatment after weight regain. The trial is supported by the pharmaceutical company, and it cannot be directly inferred that taking it every other week, splitting the dose, or reducing the dose at any time will have the same effect.
When you are close to the target, you can start talking
If you want to reduce costs, improve discomfort, or want to know how long treatment is needed, you can ask directly. Work with your doctor to decide on a maintenance plan and the extent to which your appetite or weight will return. You will need to return to the clinic early.
Is this the right time for me to discuss tapering? If you get hungry again or gain weight again after reducing your weight, what should you do next?
Original document
This article summarizes research results and care reminders and cannot replace individual diagnosis and treatment. The drugs or uses under study may not have been approved in Taiwan. Please do not change the medication or adjust the dosage accordingly.